Pancreas Transplantation

Pancreas Transplantation General

  • Pancreas transplantation E-Book
  • Who Should Be Considered for Islet Transplantation Alone?
  • Evidence-informed clinical practice recommendations for treatment of type 1 diabetes complicated by problematic hypoglycemia
  • Severe hypoglycaemia in type 1 diabetes mellitus: underlying drivers and potential strategies for successful prevention.
  • Islet cell transplants for Type 1 diabetes
  • Collaborative Islet Transplant Registery
  • Odorico JS, Sollinger HW. Technical and immunological advances in transplantation for insulin dependant diabetes mellitus.
  • Baranski AG, Lam HD, Braat AE , Schaapherder AF. The dorsal pancreatic artery in pancreas procurement and transplantation: anatomical considerations and potential implications.
  • Berney T, Badet L. Pancreas transplantation In Transplantation Surgery ed.
  • S.A. White, J.A. Shaw, D.E. Sutherland. Pancreas transplantation
  • D.E. Sutherland, R.W. Gruessner, D.L. Dunn, et al. Lessons learned from more than 1,000 pancreas transplants at a single institution.
  • J.R. Dillman, K.M. Elsayes, R.O. Bude, et al. Imaging of pancreas transplants: postoperative findings with clinical correlation.
  • F.Q. Vandermeer, M.A. Manning, A.A. Frazier, et al. Imaging of whole-organ pancreas transplants.
  • Adam D. Barlow, Kourosh Saeb-Parsy, Christopher J. E. Watson. An analysis of the survival outcomes of simultaneous pancreas and kidney transplantation compared to live donor kidney transplantation in patients with type 1 diabetes
  • Computational flow cytometry
  • Closed-loop for type 1 diabetes / an introduction and appraisal for the generalist
  • A Review of Safety and Design Requirements of the Artificial Pancreas
  • Future of Automated Insulin Delivery Systems
  • Coming of age: the artificial pancreas for type 1 diabetes
  • Feasibility of Long-Term Closed-Loop Control: A Multicenter 6-Month Trial of 24/7 Automated Insulin Delivery
  • MD-Logic Overnight Control for 6 Weeks of Home Use in Patients With Type 1 Diabetes: Randomized Crossover Trial
  • Outpatient Glycemic Control with a Bionic Pancreas in Type 1 Diabetes
  • Day and night glycaemic control with a bionic pancreas versus conventional insulin pump therapy in preadolescent children with type 1 diabetes: a randomised crossover trial
  • Closed-Loop Insulin Delivery during Pregnancy in Women with Type 1 Diabetes
  • Glucagon in arti fi cial pancreas systems: Potential bene fi ts and safety pro fi le of future chronic use
  • Home Use of an Artificial Beta Cell in Type 1 Diabetes
  • Coming of age: the artificial pancreas for type 1 diabetes
  • Outcomes after simultaneous pancreas and kidney transplantation an d the discriminative ability of the C-peptide measurement pretransplant among type 1 and type 2 diabetes mellitus.
  • Glucose homeostasis after sim ultaneous pancreas and kidney transplantation: a comparison of subjects with C-peptide-positive non-type 1 diabetes mellitus and type 1 diabetes mellitus.
  • Simultaneous pancreas-kidney transplants in type I and type II diabetic patients with end- stage renal disease: similar 10-year outcomes.
  • Simultaneous pancreas kidney transplants in diabetic patients with end-stage renal disease: the 20-yr experience.
  • Combined pancreas-kidney transpl antation for patients with end-stage nephropathy caused by type-2 diabetes mellitus.
  • Successful long-term kidney-pancreas transplants in diabetic patients with high C-peptide levels.
  • Long-term Metabolic Outcomes of Functioning Pancreas Transplants in Type 2 Diabetic Recipients.
  • Do pretransplant C-peptide levels influence outcomes in simultaneous kidney-pancreas transplantation?
  • Pancreas transplantation in C-peptide positive pa tients: does "type" of diabetes really matter?
  • Simultaneous Pancr eas and Kidney Transplantation-Is It a Treatment Option for Patients With Type 2 Diabetes Mellitus?
  • Outcomes of simultaneous pancreas-ki dney transplantation in type 2 diabetic recipients.
  • Simultaneous pancreas kidney transplant versus other kidney transplant options in pa tients with type 2 diabetes.
  • Type 2 diabetes: is pancreas transplantation an option?
  • Type 2 diabetes: the best transplant option is still uncertain.
  • Pancreas transplantation for type 2 diabetes mellitus.
  • Is there a role for pancreas transplantation in type 2 diabetes mellitus?
  • Pancreas transplantation in type II diabetes mellitus.
  • Combined pancreas and kidney transplantation in a lean type 2 diabetic patient. Effects on insulin secretion and sensitivity.
  • Maturity-onset diabetes of the young with end-stage nephropathy: a new indication for simultaneous pancreas and ki dney transplantation?
  • Successful simultaneous pancreas kidney transplantation in maturity-onset diabetes of the young type 5
  • Maturity onset diabetes of the young: clinical characteristics and outcome after kidney and pancreas transplantation in MODY3 and RCAD patients: a single center experience.
  • Practical Classification Guidelines for Diabetes in patients treated with insulin: a cross-sectional study of the accuracy of diabetes diagnosis.
  • The accelerator hypothesis: weight gain as the missing l ink between Type I and Type II diabetes.
  • The accelerator hypothesis: a review of the evidence for i nsulin resistance as the basis for type I as well as type II diabetes.

Pancreas Transplantation Module 1

Why do we need beta cell replacement when there is insulin? (Lorenzo Piemonte)
  • Understanding glucose levels in healthy subjects
  • Efficacy of insulin treatment in Type 1 diabetes patients
  • Advantages of beta cell replacement over insulin treatment
Reception Selection: Pancreas and Islet transplantation alone (Pratik Choudhary)
  • Identifying patients with problematic hypoglycaemia
  • What is the pathway for someone with problematic hypoglycemia?
  • Indications for pancreas or islet transplantation
Recipient selection: pancreas transplantation or islet grafting in uremic patients? (Olivier Thaunat)
  • Diabetes-induced vascualar complications: impact of uremia
  • Beta cell replacement in uremic T1D patient
  • Indications for islet grafting in uremic T1D patient
Recipient selection for pancreas or islet transplantation (Thierry Berney)
  • Introduction
  • Current status of pancreas vs islet transplantation
  • Preferred indications
  • Risk/benefit assessment: how are the goals achieved?
  • Risk/benefit assessment: the risks
  • Summary and decision algorithm
Pancreas transplantation for type 2 diabetes (Olivier Thaunat)
  • Introduction
  • What defines type 2 diabetes?
  • In which type 2 diabetes?
  • What is the activity?
  • How do you select candidates?

Pancreas Transplantation Module 2

Evolving approaches to organ allocation for whole pancreas versus islet transplantation (James Shaw)
  • Factors to consider for a fair and effective organ allocation scheme
  • Predictors of pancreas transplant outcome
  • Predictors of islet transplant outcome
  • Predictors of islet isolation and transplant outcome
  • Evolution of pancreas and islet transplantation in the UK
  • The UK allocation scheme: design and outcomes
Pancreas transplantation: the surgical procedure and its variation (Gabriel Oniscu)
  • Indications for, and types of, pancreas transplantation
  • Bench surgery preparation
  • Most common implantation technique
  • Technical variations
Technical complications of pancreas transplantation (Gabriel Oniscu)
  • Introduction and overview
  • Risk factors for technical complications
  • Most common technical complications
  • Other technical complications
Immunosuppressive regiments in pancreas and islet transplantation (Olivier Thaunat)
  • Pathophysiology and treatment of pancreas Tx rejection
  • Maintenance immunosuppression in pancreas transplantation
  • Immunosuppression in islet grafting
Outcome measures of immunologic mechanisms (Paolo Monti)
  • Immune monitoring of auto reactive T cell responses
  • The CFSE dilution assay
  • Staining with HLA-peptide multimers
  • High dimensional flow cytometry
  • Conclusions and next step
The incidence, diagnosis and management of pancreas rejection (biopsy) (Fabio Vistoli)
  • Introduction
  • Pancreas rejection incidence
  • Pancreas rejection diagnosis
  • Pancreas rejection management - biopsy indication
  • Pancreas rejection management - biopsy procedure
Towards the artificial pancreas (Daniela Bruttomesso)
  • Articial Pancreas: background and foundation
  • Uni-hormonal artificial pancreas: clinical evidence
  • The bi-hormonal articial pancreas
  • Towards commercialisation
  • User acceptance and possible improvements