Islet Transplantation

Thierry Berney & Lorenzo Piemonti: February 2018

Islet Transplantation General

0 CME Credits 

  • Islet Transplantation E-book
  • National Institutes of Health–Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities
  • 25 years of the ricordi automated method for islet isolation
  • GMP Facilities for Clinical Cell Therapy Product Manufacturing: A Brief Review of Requirements and Design Considerations
  • Computational flow cytometry
  • Collaborative Islet Transplant Registery
  • Evidence-informed clinical practice recommendations for treatment of type 1 diabetes complicated by problematic hypoglycemia
  • Islet cell transplants for Type 1 diabetes
  • Severe hypoglycaemia in type 1 diabetes mellitus: underlying drivers and potential strategies for successful prevention.
  • Who Should Be Considered for Islet Transplantation Alone?
  • Outcomes after simultaneous pancreas and kidney transplantation and the discriminative ability of the C-peptide measurement pretransplant among type 1 and type 2 diabetes mellitus.
  • Glucose homeostasis after sim ultaneous pancreas and kidney transplantation: a comparison of subjects with C-peptide-positive non-type 1 diabetes mellitus and type 1 diabetes mellitus.
  • Simultaneous pancreas-kidney transplants in type I and type II diabetic patients with end- stage renal disease: similar 10-year outcomes.
  • Simultaneous pancreas kidney transplants in diabetic pati ents with end-stage renal disease: the 20-yr experience.
  • Combined pancreas-kidney transplantation for patients with end-stage nephropathy caused by type-2 diabetes mellitus.
  • Successful long-term kidney-pancreas transplants in diabetic patients with high C-peptide levels.
  • Long-term Metabolic Outcomes of Functioning Pancreas Transplants in Type 2 Diabetic Recipients.
  • Do pretransplant C-peptide levels influence outcomes in simultaneous kidney-pancreas transplantation?
  • Pancreas transplantation in C-peptide positive pa tients: does "type" of diabetes really matter?
  • Outcomes of simultaneous pancreas-kidney transplantation in type 2 diabetic recipients.
  • Simultaneous pancreas kidney transplant versus other kidney transplant options in patients with type 2 diabetes.
  • Simultaneous Pancreas and Kidney Transplantation-Is It a Treatment Option for Patients With Type 2 Di abetes Mellitus?
  • Annual Data Report: Pancreas.
  • Is there a role for pancreas transplantation in type 2 diabetes mellitus?
  • Pancreas transplantation for type 2 diabetes mellitus.
  • Type 2 diabetes: the best transplant option is still uncertain.
  • Type 2 diabetes: is pancreas transplantation an option?
  • Pancreas transplantation in type II diabetes mellitus.
  • Combined pancreas and kidney transplantation in a lean type 2 diabetic patient.
  • Maturity-onset diabetes of the young with end-stage nephropathy: a new indication for simultaneous pancreas and kidney transplantation?
  • Successful simultaneous pancreas kidney transplantation in maturity-onset diabetes of the young type 5.
  • Maturity onset diabetes of the young: clinical characteristics and outcome after kidney and pancreas transplantation in MODY3 an d RCAD patients: a single center experience.
  • ractical Classification Guidelines for Diabetes in patients treated with insulin: a cross-sectional study of the accuracy of diabetes diagnosis.
  • The accelerator hypothesis: weight gain as the missing link between Type I and Type II diabetes.
  • The accelerator hypothesis: a review of the evidence for insulin resistance as the basis for type I as well as type II diabetes.
  • A Review of Safety and Design Requirements of the Artificial Pancreas
  • Closed-loop for type 1 diabetes / an introduction and appraisal for the generalist
  • Closed-Loop Insulin Delivery during Pregnancy in Women with Type 1 Diabetes
  • Coming of age: the artificial pancreas for type 1 diabetes
  • Day and night glycaemic control with a bionic pancreas versus conventional insulin pump therapy in preadolescent children with type 1 diabetes: a randomised crossover trial
  • Feasibility of Long-Term Closed-Loop Control: A Multicenter 6-Month Trial of 24/7 Automated Insulin Delivery
  • Future of Automated Insulin Delivery Systems
  • Home Use of an Artificial Beta Cell in Type 1 Diabetes
  • MD-Logic Overnight Control for 6 Weeks of Home Use in Patients With Type 1 Diabetes: Randomized Crossover Trial
  • Outpatient Glycemic Control with a Bionic Pancreas in Type 1 Diabetes
  • Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia.
  • Efficient differentiation of human embryonic stem cells to definitive endoderm.
  • A scalable system for production of functional pancreatic progenitors from human embryonic stem cells.
  • Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells.
  • Generation of functional human pancreatic β cells in vitro.
  • Induction of pluripotent stem cells from adult human fibroblasts by defined factors.
  • Generation of stem cell-derived β-cells from patients with type 1 diabetes.
  • Cells derived from iPSC can be immunogenic - yes or no?
  • Immunogenicity of induced pluripotent stem cells
  • Lack of immune response to differentiated cells derived from syngeneic induced pluripotent stem cells.
  • Advances in islet encapsulation technologies
  • Toward beta cell replacement for diabetes.
  • Maturation and function of human embryonic stem cell-derived pancreatic progenitors in macroencapsulation devices following transplant into mice.
  • Pancreatic Tissue Transplanted in TheraCyte Encapsulation Devices Is Protected and Prevents Hyperglycemia in a Mouse Model of Immune-Mediated Diabetes.
  • Autologous Pluripotent Stem Cell-Derived β-Like Cells for Diabetes Cellular Therapy.

Islet Transplantation Module 1

3 CME Credits 

Why do we need beta cell replacement when there is insulin? (Lorenzo Piemonte)
  • Understanding glucose levels in healthy subjects
  • Efficacy of insulin treatment in Type 1 diabetes patients
  • Advantages of beta cell replacement over insulin treatment
The Islet Isolation Laboratory (Hanne Scholz)
  • The infrastructure and regulatory requirements
  • What is required for the islet isolation lab?
  • The set up of the islet lab
  • The quality managment of the islet product
  • Challenges and summary of the islet isolation lab
Recipient selection for pancreas or islet transplantation alone (Pratik Choudhary)
  • Identifying patients with problematic hypoglycaemia
  • What is the pathway for someone with problematic hypoglycemia?
  • Indications for pancreas or islet transplantation
Recipient selection: pancreas transplantation or islet grafting in uremic patients? (Olivier Thaunat)
  • Diabetes-induced vascualar complications: impact of uremia
  • Beta cell replacement in uremic T1D patient
  • Indications for islet grafting in uremic T1D patient
Recipient selection for pancreas or islet transplantation (Thierry Berney)
  • Introduction
  • Current status of pancreas vs islet transplantation
  • Preferred indications
  • Risk/benefit assessment: how are the goals achieved?
  • Risk/benefit assessment: the risks
  • Summary and decision algorithm
Evolving approaches to organ allocation for whole pancreas versus islet transplantation (James Shaw)
  • Factors to consider for a fair and effective organ allocation scheme
  • Predictors of pancreas transplant outcome
  • Predictors of islet transplant outcome
  • Predictors of islet isolation and transplant outcame
  • Evolution of pancreas and islet transplantation in the UK
  • The UK allocation scheme: design and outcomes

Islet Transplantation Module 2

2 CME Credits 

Islet transplantation procedure and complications. Radiological approach (Francesco De Cobelli)
  • How to perform a Percutanous Transplantation of human pancreatic islet cells
  • How to recognize and to prevent the main complications
Immunosuppresive regimens in pancreas and islet transplantation (Olivier Thaunat)
  • Pathophysiology and treatment of pancreas Tx rejection
  • Maintenance immunosuppression in pancreas transplantation
  • Immunosuppression in islet grafting
Outcome measures of immunologic mechanisms (Paolo Monti)
  • Immune monitoring of auto reactive T cell responses
  • The CFSE dilution assay
  • Staining with HLA-peptide multimers
  • High dimensional flow cytometry
Islet Auto-transplantation beyond chronic pancreatitis (Lorenzo Piemonti)
  • Islet isolation and autotransplantation in human
  • Extended indication for islet autotransplantation
  • The Milan Protocol
Towards the artificial pancreas (Daniela Bruttomesso)
  • Articial Pancreas: background and foundation
  • Uni-hormonal artificial pancreas: clinical evidence
  • The bi-hormonal articial pancreas
  • Towards commercialisation
  • User acceptance and possible improvements
Stem cells as a source of insulin producing cells (Valeria Sordi)
  • Need for new sources
  • Embryonic stem cells (ESC)
  • Induced pluripotent stem cells (iPSC)
  • Immunogenicity and safety
  • Key take-away messages