Immunology

Oriol Bestard, Barcelona 2018

Immunology General

  • Disappearance of T Cell-Mediated Rejection Despite Continued Antibody-Mediated Rejection in Late Kidney Transplant Recipients.
  • Endothelial chimerism and vascular sequestration protect pancreatic islet grafts from antibody-mediated rejection.
  • Recent advance sin renal transplantation: antibody-mediated rejection takes center stage.
  • Detection of C3d-binding donor-specific anti-HLA antibodies at diagnosis of humoral rejection predicts renal graft loss.
  • Fundamental Immunology.
  • Tracking donor-reactive T cells: Evidence for clonal deletion in tolerant kidney transplant patients.
  • Mechanisms of MixedChimerism-Based TransplantTolerance.

Immunology Module 1

3 CME Credits 

Immunopathology of transplant rejection: Basic concepts in allograft rejection (Olivier Thaunat)
  • Molecular bases of allorecognition
  • Immunopathology of T-cell mediated rejection (TCMR)
  • Immunopathology of antibody-mediated rejection (AMR)
T-cell immunoregulation (Fadi Issa)
  • Introduction to regulatory T cells
  • Tregs Part 1
  • Tregs Part 2
  • Tregs in the clinic
Current and novel concepts in histocompatibility and immunogenetics (Sebastiaan Heidt)
  • Serological HLA typing
  • Molecular HLA typing
  • Serological crossmatching
  • Antibody screening and virtual crossmatch
  • Towards epitope matching
Impact of anti-HLA antibodies: why, when and how to measure? (Lionel Couzi)
  • Detection and characterization of donor-specific anti-HLA antibodies with crossmatch
  • Detection and characterization of donor-specific anti-HLA antibodies : Luminex single antigen bead assay
  • Detection and characterization of donor-specific anti-HLA antibodies: Analysis of the complement-binding ability and IgG subclasses of anti-HLA antibodies
  • Donor-specific anti-HLA antibodies and kidney allograft injury
  • Impact of pretransplant donor-specific anti-HLA antibodies
  • Impact of posttransplant donor-specific anti-HLA antibodies
How to refine humoral immunity through the assessment of alloreactive memory B cells (Oriol Bestard)
  • Biology of humoral memory alloimmunity
  • Evaluation of circulating donor-reactive mBC to refine the allogeniec B-cell repertoire beyond circulating DSA
  • Impact of circulating donor-reactive mBC on Kidney graft Outcomes
  • Memory B cells as a target therapy in Transplantation
  • Transplant settings to assess the presence of Circulating donor-reactive mBC

Immunology Module 2

2 CME Credits 

Cellular alloreactivity: can we monitor it? (Paolo Cravedi)
  • Why do we need biomarkers in kidney transplantation?
  • The enzyme-linked immunospot (ELISpot)
  • Urinary chemokines
  • Exhausted T cells
Novel non-invasive biomarkers of transplant alloreactivity and tolerance (Maarten Naesens)
  • The paradigm of personalized medicine
  • Diagnostic accuracy of currently used biomarkers
  • Development of novel biomarkers for rejection and immune quiescence
  • Biomarkers for operational tolerance
Induction of Tolerance in Kidney Transplantation (Julien Zuber)
  • Mixed chimerism
  • CKBMT protocol with sustained chimerism
  • CKBMT protocol with transient chimerism
  • Looking at the future