INTRODUCTION
Welcome to The Science of ECP in Solid Organ Transplantation course
Around 25% of organ transplant recipients encounter acute rejection within the initial year post-transplantation. Acute rejection is further categorised into cellular (ACR) and antibody-mediated (AMR) forms. Over the long term, the threat shifts to chronic rejection, posing a risk to graft function and patient survival. Finding a balance between the beneficial and adverse effects of immunosuppression in preventing or treating rejection is challenging. Factors such as opportunistic infections and malignancies contribute to this challenge. Consequently, there is a keen interest in therapies that can effectively modulate alloimmune responses without suppressing immune responses to infection or malignancy. Extracorporeal Photopheresis (ECP) presents a potential for this approach in organ transplantation, yet its precise mechanism of action is still to be determined.Learning objectives:
After finalising this course, participants will be able:
- To provide an overview of the role of ECP in solid organ transplantation and why understanding its MoA is important clinically
- To review the latest understanding on its MoA and how this is being used to treat transplant recipients in different clinical scenarios.
The course is accessible to everyone - Physicians, Scientists, Allied Health Care Professionals, Nurses, Patients - however, to receive a certificate of attendance, you need to be an ESOT member and logged into your Transplant Live account. Not an ESOT Member? Please visit the ESOT website to learn more.
Programme
| Lecture title | Speaker’s details |
| Module 1: Introduction to the Process of Immunomodulation and the Impact on Life | Julie Guest |
| Module 2: Biology – How does ECP work and what is the scientific rationale | Andrew Gennery |
| Module 3: The Science of ECP in Solid Organ Transplantation programme: Heart Transplantation | Markus J. Barten |
| Module 3: The Science of ECP in Solid Organ Transplantation programme: LungTransplantation | Andrew Fisher |
| Module 3: The Science of ECP in Solid Organ Transplantation programme: Kidney Transplantation | Teresa Rampino |