MODULE 2

• Introduction

  This lecture by Andrew Gennery discusses our current understanding of the mode of action of extracorporeal photopheresis (ECP) in the treatment of rejection of solid organ allografts, using the example of paediatric haematopoietic stem cell transplantation. It is often stated that “we do not know how ECP works, and whilst we do not fully understand the entire mechanism, it is clear that ECP is an immunomodulatory treatment that induces peripheral immune tolerance through the induction of peripheral regulatory T-lymphocytes. Some of the data that aids our understanding of the mechanism of action is presented.
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  Biology – how does it work and what is the scientific rationale
  

  
  

• Self-assessment quiz

  Please take the following quiz to test your understanding of this lecture

• Biology – how does it work and what is the scientific rationale H5P

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• Suggested resources

• • Barten MJ, Fisher AJ, Hertig A. The use of extracorporeal photopheresis in solid organ transplantation—current status and future directions. Am J Transplant 2024;24: 1731–1741
  • Knobler R, Arenberger P, Arun A, Assaf C, Bagot M, Berlin G, Bohbot A, Calzavara-Pinton P, Child F, Cho A, French LE, Gennery AR, Gniadecki R, Gollnick HPM, Guenova E, Jaksch P, Jantschitsch C, Klemke C, Ludvigsson J, Papadavid E, Scarisbrick J, Schwarz T, Stadler R, Wolf P, Zic J, Zouboulis C, Zuckermann A, Greinix H. European dermatology forum: Updated guidelines on the use of extracorporeal photopheresis 2020 - Part 2. J Eur Acad Dermatol Venereol. 2021 Jan;35(1):27-49. doi: 10.1111/jdv.16889.