MODULE 3

• Introduction

  This lecture by Markus J. Barten provides an overview of the indications for ECP in heart transplantation to address the unmet needs like antibody mediated rejection, calcineurin inhibitor related nephrotoxicity, cytomegalie virus infections, chronic rejection and malignancies. It will show the advantages of ECP related immunmodulation to avoid or to combat these clinical events.
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  Application in different organs - Heart

  
  

• Self-assessment quiz

  Please take the following quiz to test your understanding of this lecture

• The Science of ECP in Solid Organ Transplantation programme:Heart Transplantation H5P

  Mark as done
• Suggested resources

• • Barten MJ, Fisher AJ, Hertig A. The use of extracorporeal photopheresis in solid organ transplantation-current status and future directions. Am J Transplant. 2024 Oct;24(10):1731-1741. https://doi.org/10.1016/j.ajt.2024.03.012. 
  • Barten MJ, Dieterlen MT. Extracorporeal photopheresis after heart transplantation. Immunotherapy. 2014;6(8):927–944. https://doi.org/10.2217/imt.14.69.
  • Barten MJ, Sax B, Schopka S, et al. European multicenter study on the real-world use and clinical impact of extracorporeal photopheresis after heart transplantation. J Heart Lung Transplant. 2023;42(8):1131–1139. https://doi.org/10.1016/j.healun.2023.03.005.
  • Barten MJ, Grahammer F. The enigma of heart-kidney transplantation. Transplantation. 2023 Sep 1;107(9):1877-1879. https://doi.org/10.1097/TP.0000000000004662.
  • Barr ML, Meiser BM, Eisen HJ, et al. Photopheresis for the prevention of rejection in cardiac transplantation. Photopheresis Transplantation Study Group. N Engl J Med. 1998;339(24):1744–1751. https://doi.org/10.1056/NEJM199812103392404.
  • Barr ML, Baker CJ, Schenkel FA, et al. Prophylactic photopheresis and chronic rejection: effects on graft intimal hyperplasia in cardiac transplantation. Clinical Transplant. 2000;14(2):162–166. https://doi.org/10.1034/j.1399-0012.2000.140211.x.